Journal article
Long-lasting effects of very preterm birth on brain structure in adulthood: A systematic review and meta-analysis
CE Kelly, M Shaul, DK Thompson, RM Mainzer, JY Yang, T Dhollander, JL Cheong, TE Inder, LW Doyle, PJ Anderson
Neuroscience and Biobehavioral Reviews | Published : 2023
Abstract
Early life experiences, such as very preterm (VP) birth, can affect brain and cognitive development. Several prior studies investigated brain structure in adults born VP; synthesising these studies may help to provide a clearer understanding of long-term effects of VP birth on the brain. We systematically searched Medline and Embase for articles that investigated brain structure using MRI in adulthood in individuals born VP (<32 weeks’ gestation) or with very low birth weight (VLBW; <1500 g), and controls born at term or with normal birth weight. In total, 77 studies met the review inclusion criteria, of which 28 studies were eligible for meta-analyses, including data from up to 797 VP/VLBW ..
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Grants
Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
This study was supported through an Australian Government Research Training Program (RTP) Scholarship (to CEK), Monash University Graduate Excellence Scholarship (to CEK), the Australian National Health and Medical Research Council (Centre of Research Excellence 1153176, Investigator Grant 1176077 to PJA, Career Development Fellowship 1160003 to DKT, and Career Development Fellowship 1141354 to JLYC), The Royal Children's Hospital Foundation (RCH 1000 and RCHF 2022-1402 to JYMY), Murdoch Children's Research Institute, The University of Melbourne Department of Paediatrics, and the Victorian Government's Operational Infrastructure Support Program. The funding sources had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.